Abstract
Agmatine, an amine and organic cation, reduced H(2)O(2) that was generated by hyperglycemia, and transcription factors such as NF-kappaB and AP-1 activity in the mesangial cells that were exposed to high glucose. However, spermine which shares a strong nucleophilic structure with agmatine decreased the H(2)O(2) levels and AP-1, but not the NF-kappaB activity. Possible roles for agmatine and spermine in decreasing fibronectin are discussed, and the signaling pathway for agmatine-reduced fibronectin accumulation is presented.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Agmatine / metabolism
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Agmatine / pharmacology*
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Animals
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Cells, Cultured
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Dose-Response Relationship, Drug
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Fibronectins / metabolism
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Glomerular Mesangium / cytology
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Glomerular Mesangium / drug effects*
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Glomerular Mesangium / metabolism
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Glucose / pharmacology*
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Hydrogen Peroxide / metabolism*
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Mice
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NF-kappa B / metabolism
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Polyamines / pharmacology
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Reactive Oxygen Species / metabolism
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Signal Transduction
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Spermine / pharmacology
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Transcription Factor AP-1 / metabolism
Substances
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Fibronectins
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NF-kappa B
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Polyamines
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Reactive Oxygen Species
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Transcription Factor AP-1
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Spermine
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Agmatine
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Hydrogen Peroxide
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Glucose