Abstract
The synthesis of novel gramicidin S analogues having additional functionalities in the turn region by employing a biomimetic approach is described. The preservation of beta-sheet character in all analogues was established by NMR and the biological activity was evaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Gramicidin / analogs & derivatives*
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Gramicidin / chemical synthesis
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Gramicidin / pharmacology*
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Microbial Sensitivity Tests
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Molecular Mimicry
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Nuclear Magnetic Resonance, Biomolecular
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Protein Structure, Secondary