The primary focus in occupational injury management is the prevention of injuries before they take place through standard precautions, personal protective equipment, and administrative, work practice, and engineering controls. However, should an exposure occur, prompt and appropriate response may reduce the risk of bloodborne pathogen transmission. The Centers for Disease Control and Prevention (CDC) recently released an updated guideline for postexposure management after occupational exposure to hepatitis B, hepatitis C, or human immunodeficiency virus. This article reviews the steps that should be taken to prevent exposure to bloodborne pathogens as well as the appropriate response in the event of an exposure. In addition, the CDC's updated guidelines for postexposure management will be reviewed.