Abstract
Pulsed-field gel electrophoresis (PFGE) was performed on 122 neonatal bloodstream isolates of group B streptococci (GBS) to further examine the relationship between macrolide resistance and serotype V GBS (GBS-V). Over one-third (35%) of macrolide-resistant GBS belonged to a single PFGE subtype of GBS-V, which was also the most common GBS-V subtype noted in previous Centers for Disease Control and Prevention surveillance studies. Erm methylase (ermA and ermB) was the most common resistance mechanism detected, present in 12 of 20 macrolide-resistant GBS.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Bacterial Agents / pharmacology*
-
Bacteremia / microbiology
-
Bacterial Proteins / genetics
-
Blood / microbiology*
-
Drug Resistance, Bacterial / genetics*
-
Electrophoresis, Gel, Pulsed-Field
-
Humans
-
Infant, Newborn
-
Macrolides
-
Methyltransferases / genetics
-
Microbial Sensitivity Tests
-
Molecular Epidemiology*
-
Serotyping
-
Streptococcal Infections / microbiology
-
Streptococcus agalactiae / classification
-
Streptococcus agalactiae / drug effects*
-
Streptococcus agalactiae / genetics*
-
Streptococcus agalactiae / isolation & purification
Substances
-
Anti-Bacterial Agents
-
Bacterial Proteins
-
Macrolides
-
Methyltransferases