Relative binding activity of new antigestagens with progesterone receptors in human hyperplastic endometrium

A V Kamernitskii; I S Levina; E N Kareva; N V Kirpichnikova; K K Mgdesyan; E V Ovchinnikova

doi:10.1023/a:1022682028745

Relative binding activity of new antigestagens with progesterone receptors in human hyperplastic endometrium

Bull Exp Biol Med. 2002 Nov;134(5):445-7. doi: 10.1023/a:1022682028745.

Authors

A V Kamernitskii¹, I S Levina, E N Kareva, N V Kirpichnikova, K K Mgdesyan, E V Ovchinnikova

Affiliation

¹ Laboratory of Steroids and Terpenoids, Institute of Organic Chemistry, Russian Academy of Sciences, Moscow.

PMID: 12802447
DOI: 10.1023/a:1022682028745

Abstract

We determined the content and binding capacity of progesterone receptors in the endometrium of patients with adenomatous and fibroid polyps, adenocystic hyperplasia, and atypical hyperplasia before and after gestagen therapy. Hyperplasia of the endometrium was accompanied by changes in affinity of cytosolic progesterone receptors for antigestagens, which provides the possibility of individual correction of hormone therapy.

MeSH terms

17 alpha-Hydroxyprogesterone Caproate
Adult
Endometrial Hyperplasia / drug therapy
Endometrial Hyperplasia / metabolism*
Endometrial Hyperplasia / pathology
Estrogen Receptor Modulators / metabolism*
Estrogen Receptor Modulators / therapeutic use
Female
Humans
Hydroxyprogesterones / therapeutic use
In Vitro Techniques
Kinetics
Middle Aged
Receptors, Progesterone / drug effects
Receptors, Progesterone / metabolism*

Substances

Estrogen Receptor Modulators
Hydroxyprogesterones
Receptors, Progesterone
17 alpha-Hydroxyprogesterone Caproate