Phase recovery and lensless imaging by iterative methods in optical, X-ray and electron diffraction

Philos Trans A Math Phys Eng Sci. 2002 May 15;360(1794):875-95. doi: 10.1098/rsta.2001.0972.

Abstract

Thomas Young's quantitative analysis of interference effects provided the confidence needed to revive the wave theory of light, and firmly established the concept of phase in optics. Phase plays a similarly fundamental role in matter-wave interferometry, for which the field-emission electron microscope provides ideal instrumentation. The wave-particle duality is vividly demonstrated by experimental 'Young's fringes' using coherent electron beams under conditions in which the flight time is less than the time between particle emission. A brief historical review is given of electron interferometry and holography, including the Aharonov-Bohm effect and the electron Sagnac interferometer. The simultaneous development of phase-contrast imaging at subnanometre spatial resolution has greatly deepened our understanding of atomic processes in biology, materials science and condensed-matter physics, while electron holography has become a routine tool for the mapping of electrostatic and magnetic fields in materials on a nanometre scale. The encoding of phase information in scattered farfield intensities is discussed, and non-interferometric, non-crystallographic methods for phase retrieval are reviewed in relationship to electron holography. Examples of phase measurement and diffraction-limited imaging using the hybrid input-output iterative algorithm are given, including simulations for soft X-ray imaging, and new experimental results for coherent electron and visible-light scattering. Image reconstruction is demonstrated from experimental electron and visible-light Fraunhofer diffraction patterns. The prospects this provides for lensless imaging using particles for which no lenses exist (such as neutrons, condensates, coherent atom beams and X-rays) are discussed. These new interactions can be expected to provide new information, perhaps, for example, in biology, with the advantage of less damage to samples.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Algorithms*
  • Holography / instrumentation
  • Holography / methods
  • Humans
  • Image Enhancement / instrumentation
  • Image Enhancement / methods*
  • Lenses
  • Microscopy, Electron / instrumentation
  • Microscopy, Electron / methods*
  • Microscopy, Interference / instrumentation
  • Microscopy, Interference / methods*
  • Phantoms, Imaging
  • X-Ray Diffraction / instrumentation
  • X-Ray Diffraction / methods*