Abstract
Host T-cell response to Helicobacter pylori is important for the clinical outcome of the infection. A Th1-polarized response, preferentially against CagA, is associated with peptic ulcer, whereas mixed Th1 and Th0 responses are present in non-ulcer gastritis. A deregulated H. pylori-driven Th0 cell-dependent B-cell activation is found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antigens, Bacterial / immunology
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Chronic Disease
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Gastric Mucosa / immunology
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Gastritis / immunology
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Helicobacter Infections / immunology*
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Helicobacter pylori / immunology*
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Humans
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Lymphoma, B-Cell, Marginal Zone / immunology
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Stomach Diseases / immunology*
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Stomach Neoplasms / immunology
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Stomach Ulcer / immunology
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T-Lymphocytes / immunology*