Abstract
Knock-out mice lacking the serotonin transporter [5-hydroxytryptamine transporter (5-HTT)] were used to assess the influence of 5-HT re-uptake on ethanol consumption. Under a free-choice paradigm, alcohol intake was lower in mutant than in wild-type mice, and pharmacological blockade of 5-HTT by fluoxetine reduced alcohol intake in wild-type mice only. These data confirm the inhibitory effect of 5-HTT inactivation on ethanol intake.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohol Drinking / genetics*
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Alcohol Drinking / metabolism*
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Animals
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Carrier Proteins / genetics*
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Carrier Proteins / metabolism*
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Ethanol / administration & dosage
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Female
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Gene Deletion*
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Male
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Membrane Glycoproteins / genetics*
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Membrane Glycoproteins / metabolism*
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Membrane Transport Proteins*
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Nerve Tissue Proteins*
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Serotonin Plasma Membrane Transport Proteins
Substances
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Carrier Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Serotonin Plasma Membrane Transport Proteins
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Slc6a4 protein, mouse
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Ethanol