Abstract
We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins. We also identified previously unknown candidates for secreted neuroactive molecules. The existence of a large number of unique brain ESTs suggests an additional molecular complexity that remains to be explored.A list of genes containing CAG stretches in the coding region represents a first step in the potential identification of candidates for hereditary neurological disorders.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenine / metabolism
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Amino Acid Sequence
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Animals
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Brain Chemistry / genetics
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Calcium / physiology
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Calcium Channels / genetics
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Calcium Channels / physiology
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Chloride Channels / genetics
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Chloride Channels / physiology
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Cytosine / metabolism
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Databases, Genetic
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GTP-Binding Proteins / genetics
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Gene Library
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Genes / genetics
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Genes / physiology*
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Guanine / metabolism
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Humans
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Mice
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Molecular Sequence Data
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Nervous System / chemistry*
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Nervous System / metabolism*
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Nervous System Physiological Phenomena*
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Neurodegenerative Diseases / genetics
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Neurons / chemistry
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Neurons / metabolism
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Neurons / physiology
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Neuropeptides / genetics
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Phylogeny
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Receptors, Cell Surface / genetics
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Transcription, Genetic / genetics*
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Trinucleotide Repeat Expansion / genetics
Substances
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Calcium Channels
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Chloride Channels
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Neuropeptides
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Receptors, Cell Surface
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Guanine
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Cytosine
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GTP-Binding Proteins
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Adenine
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Calcium