Abstract
Nitric oxide (NO) is an endogenous neuromodulator that may mediate neurotoxic effects of glutamate. NO-synthesizing neurons are, however, resistant to NO- and glutamate-induced neurotoxicity. We now show that NO synthase neurons are selectively spared in patients with Alzheimer's disease, even in a severely affected region of the brain such as the hippocampal formation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Aged, 80 and over
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Alzheimer Disease / enzymology*
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Alzheimer Disease / pathology
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Amino Acid Oxidoreductases / metabolism*
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Hippocampus / enzymology*
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Hippocampus / pathology
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Humans
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Neurons / enzymology*
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Neurons / pathology
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Nitric Oxide Synthase
Substances
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Nitric Oxide Synthase
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Amino Acid Oxidoreductases