Abstract
We compared the activities of telithromycin, erythromycin, azithromycin, josamycin, penicillin G, amoxicillin, cefpodoxime, and ceftriaxone against invasive and noninvasive non-penicillin-susceptible Streptococcus pneumoniae isolates recovered from children. Of the 186 isolates tested, 89% were positive for erm(B) by PCR. Telithromycin had the lowest MICs, with MICs at which 90% of the isolates tested are inhibited of 0.032 and 0.25 micro g/ml for erythromycin-sensitive and -resistant isolates, respectively.
MeSH terms
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Amoxicillin / pharmacology
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Anti-Bacterial Agents / pharmacology*
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Azithromycin / pharmacology
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Cefpodoxime
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Ceftizoxime / analogs & derivatives*
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Ceftizoxime / pharmacology
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Ceftriaxone / pharmacology
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Child
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Drug Resistance, Bacterial
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Erythromycin / pharmacology
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France
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Humans
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In Vitro Techniques
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Josamycin / pharmacology
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Ketolides*
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Macrolides*
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Penicillin G / pharmacology
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Penicillin Resistance
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Penicillins / pharmacology
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Pneumococcal Infections / drug therapy*
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Streptococcus pneumoniae / drug effects*
Substances
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Anti-Bacterial Agents
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Ketolides
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Macrolides
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Penicillins
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Erythromycin
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Ceftriaxone
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Amoxicillin
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Azithromycin
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Ceftizoxime
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Josamycin
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telithromycin
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Penicillin G