Abstract
Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-aminopiperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9, active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amnesia / chemically induced
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Amnesia / drug therapy
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Animals
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Avoidance Learning / drug effects
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Chemical Phenomena
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Chemistry, Physical
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Cognition / drug effects*
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Dose-Response Relationship, Drug
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Indicators and Reagents
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Mice
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Muscarinic Antagonists
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Neurodegenerative Diseases / drug therapy
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Neurodegenerative Diseases / pathology
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Nootropic Agents / chemical synthesis*
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Nootropic Agents / pharmacology
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Piperidines / chemical synthesis*
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Piperidines / pharmacology
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Receptors, AMPA / drug effects
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Scopolamine
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Structure-Activity Relationship
Substances
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4-aminopiperidine
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Indicators and Reagents
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Muscarinic Antagonists
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Nootropic Agents
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Piperidines
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Receptors, AMPA
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Scopolamine