Cell transplantation to improve ventricular function in the failing heart

Eur J Cardiothorac Surg. 2003 Jun;23(6):907-16. doi: 10.1016/s1010-7940(03)00140-4.

Abstract

Current therapies for congestive heart failure are limited in efficacy or in applicability. Cardiac cell transplantation offers a novel therapeutic approach to improve heart function. Although significant progress has been made over the past decade in the development of cell transplantation, only recently have investigators studied the changes in ventricular function following cell transplantation. This review article describes the latest research developments, evaluates recent studies of ventricular function after cell transplantation, and discusses the future directions of cell transplantation as a new therapy to 'repair broken hearts'.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Marrow Transplantation
  • Echocardiography
  • Electric Conductivity
  • Heart Failure / diagnosis
  • Heart Failure / etiology
  • Heart Failure / surgery*
  • Models, Animal
  • Myocardial Ischemia / complications
  • Myocardial Ischemia / diagnosis
  • Myocytes, Cardiac / transplantation*
  • Perfusion
  • Tomography, Emission-Computed, Single-Photon
  • Ventricular Dysfunction / diagnosis
  • Ventricular Dysfunction / etiology
  • Ventricular Dysfunction / surgery*