Pattern recognition methods in evaluation of the structure of the laboratory data biominerals, antioxidant enzymes, selected biochemical parameters, and pulmonary function of welders

Biol Trace Elem Res. 2003 Summer;93(1-3):39-46. doi: 10.1385/BTER:93:1-3:39.

Abstract

A wide set of biochemical and spirometrical parameters was applied to a group of 41 welders. The obtained parameters were analyzed by the pattern recognition method: principal-components analysis (PCA) and mutual contribution analysis (MCA). The aim of the investigation was to find out which of 23 parameters had an influence on the pulmonological indices of COPD. It was found that PCA gave a substantial reduction of dimensionality. The most relevant parameters were Fe, Zn, Cu (all elements in blood, not in hair), FEV1, MEF50, bilirubin, TAS, and SOD. Only the relationships of MEF50, Cu, and TAS were statistically valid.

MeSH terms

  • Adult
  • Age Factors
  • Air Pollutants, Occupational / analysis
  • Air Pollutants, Occupational / blood
  • Antioxidants / analysis*
  • Hair / chemistry
  • Humans
  • Middle Aged
  • Occupational Exposure*
  • Oxidative Stress
  • Pattern Recognition, Automated
  • Principal Component Analysis*
  • Pulmonary Disease, Chronic Obstructive / blood*
  • Pulmonary Disease, Chronic Obstructive / metabolism
  • Pulmonary Disease, Chronic Obstructive / physiopathology*
  • Respiratory Function Tests
  • Time Factors
  • Trace Elements / analysis*
  • Trace Elements / blood
  • Welding*

Substances

  • Air Pollutants, Occupational
  • Antioxidants
  • Trace Elements