Conformation and recognition control of peptide ribonucleic acid containing pyrimidine/purine mixed sequence

H Sato; T Wada; Y Inoue

doi:10.1093/nass/1.1.229

Conformation and recognition control of peptide ribonucleic acid containing pyrimidine/purine mixed sequence

Nucleic Acids Res Suppl. 2001:(1):229-30. doi: 10.1093/nass/1.1.229.

Authors

H Sato¹, T Wada, Y Inoue

Affiliation

¹ Department of Molecular Chemistry, Osaka University, 2-1 Yamada-oka, Suita 565-0871, Japan.

PMID: 12836348
DOI: 10.1093/nass/1.1.229

Abstract

Peptide ribonucleic acids (PRNA), tethering 5'-amino-5'-deoxyribonucleoside as a recognition moiety for RNA/DNA, have been designed and synthesized, as a novel nucleic acid model. External switching of the recognition behavior of PRNA containing not only pyrimidine nucleobase but also purine nucleobase, with complementary oligomeric DNA/RNA has been demonstrated for the first time through both the orientational switching of the nucleobase of PRNA and electrostatic repulsion between borate ester anion of PRNA and phosphodiester anion of DNA/RNA, induced by added borates.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Circular Dichroism
DNA / chemistry*
Deoxyribonucleosides / chemistry
Nucleic Acid Conformation
Nucleic Acid Hybridization
Peptide Nucleic Acids / chemical synthesis
Peptide Nucleic Acids / chemistry*
Purines / chemistry*
Pyrimidines / chemistry*
RNA / chemistry
Ribonucleosides / chemical synthesis
Ribonucleosides / chemistry*

Substances

Deoxyribonucleosides
Peptide Nucleic Acids
Purines
Pyrimidines
Ribonucleosides
RNA
DNA