Anteroposterior patterning in hemichordates and the origins of the chordate nervous system

Cell. 2003 Jun 27;113(7):853-65. doi: 10.1016/s0092-8674(03)00469-0.

Abstract

The chordate central nervous system has been hypothesized to originate from either a dorsal centralized, or a ventral centralized, or a noncentralized nervous system of a deuterostome ancestor. In an effort to resolve these issues, we examined the hemichordate Saccoglossus kowalevskii and studied the expression of orthologs of genes that are involved in patterning the chordate central nervous system. All 22 orthologs studied are expressed in the ectoderm in an anteroposterior arrangement nearly identical to that found in chordates. Domain topography is conserved between hemichordates and chordates despite the fact that hemichordates have a diffuse nerve net, whereas chordates have a centralized system. We propose that the deuterostome ancestor may have had a diffuse nervous system, which was later centralized during the evolution of the chordate lineage.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biological Evolution
  • Body Patterning / genetics*
  • Chordata, Nonvertebrate / cytology
  • Chordata, Nonvertebrate / embryology*
  • Chordata, Nonvertebrate / genetics
  • Ectoderm / cytology
  • Ectoderm / metabolism
  • Embryo, Nonmammalian / embryology
  • Evolution, Molecular
  • Gene Expression Regulation, Developmental / genetics*
  • Genes, Homeobox / genetics
  • Invertebrates / embryology*
  • Invertebrates / metabolism
  • Molecular Sequence Data
  • Nervous System / cytology
  • Nervous System / embryology*
  • Nervous System / metabolism
  • Phylogeny
  • Sequence Homology, Nucleic Acid
  • Vertebrates / embryology*
  • Vertebrates / metabolism

Associated data

  • GENBANK/AY313137
  • GENBANK/AY313138
  • GENBANK/AY313139
  • GENBANK/AY313140
  • GENBANK/AY313141
  • GENBANK/AY313142
  • GENBANK/AY313143
  • GENBANK/AY313144
  • GENBANK/AY313145
  • GENBANK/AY313146
  • GENBANK/AY313147
  • GENBANK/AY313148
  • GENBANK/AY313149
  • GENBANK/AY313150
  • GENBANK/AY313151
  • GENBANK/AY313153
  • GENBANK/AY313154
  • GENBANK/AY313155
  • GENBANK/AY313157
  • GENBANK/AY313158
  • GENBANK/AY313159
  • GENBANK/AY318740
  • GENBANK/AY318741