Abstract
Chemical genetics is an emerging strategy in chemical biology that promises to bring the power of true genetics to mammalian systems and facilitate the transfer of biological discoveries to therapeutics. The platelet is an anucleate cell with several features that render it suitable for chemical genetic analysis. This review addresses the benefits and challenges of chemical genetics using platelets as a model system.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Blood Platelets / drug effects*
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Blood Platelets / physiology
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GTP-Binding Proteins / metabolism
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Genetic Techniques*
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Histones / metabolism
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Humans
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Phenotype
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Platelet Activation* / drug effects
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Platelet Aggregation Inhibitors / pharmacology
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Protein-Tyrosine Kinases / metabolism
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Signal Transduction / drug effects
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Signal Transduction / genetics
Substances
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Histones
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Platelet Aggregation Inhibitors
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Protein-Tyrosine Kinases
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GTP-Binding Proteins