Abstract
The use of vinorelbine 30 mg/m2/week as a single-agent treatment in advanced breast cancer has achieved response rates of > 20% as second-line treatment and 40 to 50% as first-line treatment. The major toxicity of the drug is reversible neutropenia; 35 to 50% of treated patients have grade IV neutropenia. The agent did not induce thrombocytopenia and proved mildly emetogenic and neurotoxic. Activity was confirmed in combination with fluorouracil or doxorubicin, when response rates ranging from 60 to 74% were achieved. Thus, vinorelbine appears to be a promising agent in the treatment of advanced breast cancer.
Publication types
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Clinical Trial
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Multicenter Study
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Review
MeSH terms
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Adult
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Aged
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Antineoplastic Agents / adverse effects
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use*
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Antineoplastic Combined Chemotherapy Protocols / pharmacology
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Breast Neoplasms / drug therapy*
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Female
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Humans
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In Vitro Techniques
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Middle Aged
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Tumor Cells, Cultured / drug effects
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Vinblastine / administration & dosage
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Vinblastine / adverse effects
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Vinblastine / analogs & derivatives*
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Vinblastine / pharmacology
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Vinblastine / therapeutic use
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Vinorelbine
Substances
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Antineoplastic Agents
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Vinblastine
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Vinorelbine