Abstract
Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios. Ann Neurol 2003;54:119-122
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Abatacept
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Antigens, CD
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Antigens, Differentiation / genetics*
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CTLA-4 Antigen
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Cohort Studies
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DNA Primers / genetics
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Genetic Predisposition to Disease
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HLA-DR Antigens / genetics*
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HLA-DR Serological Subtypes
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Humans
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Immunoblotting
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Immunoconjugates*
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Multiple Sclerosis / genetics*
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Polymerase Chain Reaction
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Polymorphism, Genetic / genetics
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Promoter Regions, Genetic / genetics
Substances
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Antigens, CD
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Antigens, Differentiation
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CTLA-4 Antigen
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CTLA4 protein, human
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DNA Primers
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HLA-DR Antigens
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HLA-DR Serological Subtypes
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HLA-DR15 antigen
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Immunoconjugates
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Abatacept