Abstract
The effects of chimeric anti-CD4 human/murine chimeric antibody and murine anti-CD4 monoclonal antibody (McAb) on the proliferation induced by anti-CD3 McAb, phytohemagglutinin (PHA), IL-2, and allogeneic cells were studied. The results showed that chimeric anti-CD4 antibody and murine anti-CD4 McAb could inhibit the proliferation induced by the above inducers and the inhibitory effects were related to the dosage of the antibodies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies / immunology*
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Antibodies, Monoclonal / biosynthesis
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Antibodies, Monoclonal / genetics
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Antibodies, Monoclonal / immunology*
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Antibody-Producing Cells / immunology
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CD3 Complex / immunology
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CD4 Antigens / immunology*
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Cell Division / drug effects
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Cells, Cultured
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Humans
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Interleukin-2 / pharmacology
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Leukocytes, Mononuclear / cytology
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Leukocytes, Mononuclear / immunology
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Mice
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Mice, Inbred BALB C
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Phytohemagglutinins / pharmacology
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Recombinant Fusion Proteins / immunology*
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Recombinant Proteins / biosynthesis
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Recombinant Proteins / genetics
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Recombinant Proteins / immunology
Substances
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Antibodies
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Antibodies, Monoclonal
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CD3 Complex
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CD4 Antigens
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Interleukin-2
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Phytohemagglutinins
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Recombinant Fusion Proteins
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Recombinant Proteins