G-CSF mobilised progenitor cells in autologous transplantation: in vitro and in vivo aspects

C G Begley; E DeLuca; P A Rowlings; J Szer; D Watson; C Juttner; G Morstyn; R M Fox; W Sheridan

doi:10.3177/jnsv.38.special_368

G-CSF mobilised progenitor cells in autologous transplantation: in vitro and in vivo aspects

J Nutr Sci Vitaminol (Tokyo). 1992:Spec No:368-71. doi: 10.3177/jnsv.38.special_368.

Authors

C G Begley¹, E DeLuca, P A Rowlings, J Szer, D Watson, C Juttner, G Morstyn, R M Fox, W Sheridan

Affiliation

¹ The Royal Melbourne Hospital, Victoria, Australia.

PMID: 1284309
DOI: 10.3177/jnsv.38.special_368

Abstract

G-CSF administration leads to significant elevation in the levels of circulating progenitor cells. Infusion of these cells after high-dose chemotherapy is associated with accelerated platelet engraftment that has a considerable impact in shortening thrombocytopenia and reducing need for platelet transfusions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antineoplastic Agents / adverse effects*
Blood Component Transfusion / methods*
Bone Marrow Transplantation / adverse effects*
Cells, Cultured
Colony-Forming Units Assay
Granulocyte Colony-Stimulating Factor / therapeutic use*
Hematopoietic Stem Cells / drug effects*
Humans
Middle Aged
Risk Factors
Thrombocytopenia / drug therapy
Transplantation, Autologous

Substances

Antineoplastic Agents
Granulocyte Colony-Stimulating Factor