[Antiviral activity of some 5-arylethynyl 2'-deoxyuridine derivatives]

V L Andronova; M V Skorobogatyĭ; E V Manasova; Iu A Berlin; V A Korshun; G A Galegov

doi:10.1023/a:1023936516589

[Antiviral activity of some 5-arylethynyl 2'-deoxyuridine derivatives]

Bioorg Khim. 2003 May-Jun;29(3):290-5. doi: 10.1023/a:1023936516589.

[Article in Russian]

Authors

V L Andronova¹, M V Skorobogatyĭ, E V Manasova, Iu A Berlin, V A Korshun, G A Galegov

Affiliation

¹ Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, ul. Gamalei 16, Moscow, 123098 Russia.

PMID: 12845804
DOI: 10.1023/a:1023936516589

Abstract

5-(3-Perylenylethynyl)-2'-deoxyuridine was prepared by cross-linking 5-iodo-2'-deoxyuridine derivatives with 3-ethynylperylene followed by deprotection. 5-(1-Perylenylethynyl)-, 5-(3-perylenylethynyl)-, and 5-[4-(2-benzoxazolyl)phenylethynyl]-2'-deoxyuridine were found to inhibit in Vero cells the replication of type 1 herpes simplex virus and its drug-resistant strains.

Publication types

English Abstract

MeSH terms

Animals
Antiviral Agents / chemistry*
Antiviral Agents / pharmacology*
Cells, Cultured
Chemistry, Organic / methods
Cross-Linking Reagents / chemistry
Deoxyuridine / analogs & derivatives
Deoxyuridine / chemistry*
Drug Evaluation, Preclinical / methods
Drug Resistance, Multiple, Viral
Herpesvirus 1, Human / drug effects
Herpesvirus 1, Human / physiology
Kidney / cytology
Kidney / drug effects
Kidney / virology
Perylene / analogs & derivatives
Perylene / chemistry
Structure-Activity Relationship
Virus Replication / drug effects

Substances

Antiviral Agents
Cross-Linking Reagents
Perylene
Deoxyuridine