E2F1 and c-Myc in cell growth and death

Cell Cycle. 2003 Jul-Aug;2(4):333-8.

Abstract

Cell cycle machinery controls not only cell growth but also cell survival and death. For example, overexpression of c-Myc or E2F1, which are involved in G1/S transition, causes apoptosis under certain conditions. Furthermore, endogenous E2F1 also participates in apoptosis, as evidenced by the defect of apoptosis in E2F1-deficient mice. Candidate molecules that mediate c-Myc- and E2F1-enhanced apoptosis include p14/p19ARF, ornithine decarboxylase and lactate dehydrogenase-A (for c-Myc) as well as p14/p19ARF, p73, Apaf-1 and caspase-3 (for E2F1). c-Myc also activates the CD95/Fas-FADD-mediated death signal. c-Myc and E2F1 inhibit NF-kappaB activities induced by TNFalpha or reactive oxygen species. Therefore, c-Myc and E2F1 regulate cell growth and death not only by inducing transcription but also by modulating signal transduction pathways.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Apoptotic Protease-Activating Factor 1
  • Caspase 3
  • Caspases / metabolism
  • Cell Cycle / physiology
  • Cell Cycle Proteins*
  • Cell Death / physiology
  • Cell Division / physiology*
  • Cell Survival / physiology*
  • Cyclin-Dependent Kinase Inhibitor p16
  • DNA-Binding Proteins / metabolism
  • E2F Transcription Factors
  • E2F1 Transcription Factor
  • Genes, Tumor Suppressor
  • Helminth Proteins / metabolism
  • Mice
  • Muscle Proteins / metabolism
  • NF-kappa B / metabolism
  • Nuclear Proteins / metabolism
  • Protein Interaction Mapping
  • Proteins / metabolism
  • Proto-Oncogene Proteins c-myc / metabolism*
  • S Phase / physiology
  • Signal Transduction
  • Transcription Factors / metabolism*
  • Tumor Protein p73
  • Tumor Suppressor Protein p14ARF / metabolism
  • Tumor Suppressor Proteins
  • fas Receptor / metabolism

Substances

  • Apaf1 protein, mouse
  • Apoptotic Protease-Activating Factor 1
  • Cdkn2a protein, mouse
  • Cell Cycle Proteins
  • Cyclin-Dependent Kinase Inhibitor p16
  • DNA-Binding Proteins
  • E2F Transcription Factors
  • E2F1 Transcription Factor
  • E2f1 protein, mouse
  • Helminth Proteins
  • Muscle Proteins
  • NF-kappa B
  • Nuclear Proteins
  • Proteins
  • Proto-Oncogene Proteins c-myc
  • Transcription Factors
  • Trp73 protein, mouse
  • Tumor Protein p73
  • Tumor Suppressor Protein p14ARF
  • Tumor Suppressor Proteins
  • calponin homolog protein, Schistosoma japonicum
  • fas Receptor
  • Casp3 protein, mouse
  • Caspase 3
  • Caspases