Abstract
Several bioactive acetogenins were selective against 1A9 (ovarian cancer) cell replication but did not show a corresponding hyperactivity against other cell lines. The most active compound (26, molvizarin) was a selective inhibitor of 1A9 cell replication with a potency (ED(50) = 5 pg/mL) of over 1 million times more than that for other cell lines.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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2-Propanol / chemistry*
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Annonaceae / chemistry
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Cell Division / drug effects
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Drug Screening Assays, Antitumor
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Fatty Acids / chemistry
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Fatty Acids / isolation & purification
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Fatty Acids / pharmacology*
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Female
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Furans / chemistry
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Furans / isolation & purification
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Furans / pharmacology*
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Humans
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Ovarian Neoplasms
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Plant Preparations / chemistry
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Plant Preparations / isolation & purification
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Plant Preparations / pharmacology
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Fatty Acids
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Furans
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Plant Preparations
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2-Propanol