Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1-E2-Origin DNA complex

Christiane Yoakim; William W Ogilvie; Nathalie Goudreau; Julie Naud; Bruno Haché; Jeff A O'Meara; Michael G Cordingley; Jacques Archambault; Peter W White

doi:10.1016/s0960-894x(03)00510-9

Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1-E2-Origin DNA complex

Bioorg Med Chem Lett. 2003 Aug 4;13(15):2539-41. doi: 10.1016/s0960-894x(03)00510-9.

Authors

Christiane Yoakim¹, William W Ogilvie, Nathalie Goudreau, Julie Naud, Bruno Haché, Jeff A O'Meara, Michael G Cordingley, Jacques Archambault, Peter W White

Affiliation

¹ Department of Chemistry, Boehringer Ingelheim (Canada) Ltd., 2100 Cunard Street, Laval, Québec, Canada H7S 2G5. [email protected]

PMID: 12852961
DOI: 10.1016/s0960-894x(03)00510-9

Abstract

We have discovered a series of inhibitors of the assembly of the HPV11 E1-E2-origin DNA complex, which incorporate an indandione fused to a substituted tetrahydrofuran.

MeSH terms

Antiviral Agents / chemical synthesis*
Antiviral Agents / pharmacology*
Chromatography, High Pressure Liquid
DNA, Viral / biosynthesis*
Drug Design
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Papillomaviridae / drug effects*
Spectrophotometry, Infrared
Structure-Activity Relationship
Viral Proteins / biosynthesis
Viral Proteins / genetics
Virus Assembly / drug effects

Substances

Antiviral Agents
DNA, Viral
Viral Proteins