Abstract
To study time-scheduled regimens in the treatment of tumours by cytotoxic drugs delivered by IV injection, we propose a mathematical model of the action of a chemotherapy on the population of tumoral cells on the one hand, on a population of fast renewing healthy cells on the other hand. We chose for model parameter identification the treatment by oxaliplatin of Glasgow Osteosarcoma in mice.
MeSH terms
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Animals
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Antineoplastic Agents, Alkylating / administration & dosage
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Antineoplastic Agents, Alkylating / pharmacokinetics
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Antineoplastic Agents, Alkylating / therapeutic use*
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Antineoplastic Agents, Alkylating / toxicity
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Bone Neoplasms / drug therapy*
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Bone Neoplasms / pathology
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Cell Division / drug effects
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Cell Line, Tumor / transplantation
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Chronotherapy*
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Intestinal Mucosa / cytology
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Intestinal Mucosa / drug effects
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Jejunum / cytology
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Jejunum / drug effects
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Mice
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Models, Biological
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Neoplastic Stem Cells / drug effects
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Organoplatinum Compounds / administration & dosage
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Organoplatinum Compounds / pharmacokinetics
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Organoplatinum Compounds / therapeutic use*
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Organoplatinum Compounds / toxicity
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Osteosarcoma / drug therapy*
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Osteosarcoma / pathology
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Oxaliplatin
Substances
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Antineoplastic Agents, Alkylating
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Organoplatinum Compounds
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Oxaliplatin