Abstract
The present study investigates the activity of four gamma-hydroxybutyric acid amide analogues (BM-68, BM-74, BM-75 and BM-76) in two models of chemically induced seizures, i.e. picrotoxin- and pentetrazole-induced seizures and in the thiopental-induced sleep test. The results of pharmacological in vivo experiments with the gamma-hydroxybutyric acid amide analogues presented below show that the compounds possess variable influence on the central nervous system in mice.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Central Nervous System / drug effects*
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Central Nervous System / physiology
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Hydroxybutyrates / chemical synthesis*
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Hydroxybutyrates / pharmacology*
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Hydroxybutyrates / therapeutic use
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Male
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Mice
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Seizures / chemically induced
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Seizures / prevention & control
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Sleep / drug effects
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Sleep / physiology
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gamma-Aminobutyric Acid / analogs & derivatives*
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gamma-Aminobutyric Acid / pharmacology
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gamma-Aminobutyric Acid / therapeutic use
Substances
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Hydroxybutyrates
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4-hydroxybutyric acid
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gamma-Aminobutyric Acid