Autoimmune hepatitis revealed by atorvastatin

Eur J Gastroenterol Hepatol. 2003 Aug;15(8):921-4. doi: 10.1097/00042737-200308000-00014.

Abstract

Cases of acute hepatitis induced by statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) have been reported. A 65-year-old woman was admitted to our hospital because of fatigue, jaundice and altered liver function tests while on treatment with atorvastatin. On the basis of clinical, serological and histological findings, a score leading to a diagnosis of autoimmune hepatitis was reached. We suggest that atorvastatin may have revealed an underlying autoimmune hepatitis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Alanine Transaminase / metabolism
  • Aspartate Aminotransferases / metabolism
  • Atorvastatin
  • Autoimmune Diseases / chemically induced*
  • Autoimmune Diseases / pathology
  • Bilirubin / metabolism
  • Chemical and Drug Induced Liver Injury / etiology*
  • Chemical and Drug Induced Liver Injury / pathology
  • Female
  • Heptanoic Acids / adverse effects*
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
  • Liver / pathology
  • Liver Function Tests
  • Pyrroles / adverse effects*

Substances

  • Heptanoic Acids
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Pyrroles
  • Atorvastatin
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Bilirubin