Successful treatment of rhinocerebral mucormycosis with liposomal amphotericin B and surgery in two diabetic patients with renal dysfunction

J Chemother. 2003 Jun;15(3):282-6. doi: 10.1179/joc.2003.15.3.282.

Abstract

The zygomycetes are a class of fungi that can cause a variety of infections in humans. Rhinocerebral mucormycosis is a rare disease and usually affects diabetic or immunosuppressed patients. The disease progresses rapidly and is usually fatal despite aggressive surgical and medical therapy. We report the management of two cases of rhino-sinusal and orbital mucormycosis in diabetic patients on treatment with corticosteroids, and mild renal impairment, successfully treated with a combination of aggressive surgical debridement and liposomal amphotericin B.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / complications
  • Acute Kidney Injury / diagnosis
  • Aged
  • Amphotericin B / administration & dosage*
  • Antifungal Agents / administration & dosage
  • Combined Modality Therapy
  • Debridement / methods
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / diagnosis
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Mucormycosis / complications
  • Mucormycosis / diagnosis
  • Mucormycosis / therapy*
  • Orbital Diseases / diagnosis
  • Orbital Diseases / therapy*
  • Paranasal Sinus Diseases / complications
  • Paranasal Sinus Diseases / diagnosis
  • Paranasal Sinus Diseases / therapy*
  • Risk Assessment
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Antifungal Agents
  • Amphotericin B