Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the methylene spacer and the P1' side chain

Bioorg Med Chem Lett. 2003 Aug 18;13(16):2709-13. doi: 10.1016/s0960-894x(03)00532-8.

Abstract

Structural modifications to the peptide deformylase inhibitor BB-3497 are described. In this paper, we describe the initial SAR around this lead for modifications to the methylene spacer and the P1' side chain. Enzyme inhibition and antibacterial activity data revealed that the optimum distance between the N-formyl hydroxylamine metal binding group and the P1' side chain is one unsubstituted methylene unit. Additionally, lipophilic P1' side chains that closely mimic the methionine residue in the substrate provided compounds with the best microbiological profile.

Publication types

  • Comparative Study

MeSH terms

  • Amidohydrolases / antagonists & inhibitors*
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / pharmacology
  • Hydrocarbons
  • Hydroxamic Acids / chemistry*
  • Hydroxamic Acids / pharmacology
  • Hydroxylamine / chemistry
  • Inhibitory Concentration 50
  • Metals / chemistry
  • Methane / analogs & derivatives*
  • Methane / chemistry
  • Microbial Sensitivity Tests
  • Molecular Mimicry
  • Oligopeptides / chemistry
  • Oligopeptides / pharmacology
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • BB3497
  • Enzyme Inhibitors
  • Hydrocarbons
  • Hydroxamic Acids
  • Metals
  • Oligopeptides
  • carbene
  • Hydroxylamine
  • Amidohydrolases
  • peptide deformylase
  • Methane