Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis

Antimicrob Agents Chemother. 2003 Aug;47(8):2663-5. doi: 10.1128/AAC.47.8.2663-2665.2003.

Abstract

Children with acute otitis media underwent tympanocentesis and were given a single dose of 30 mg of azithromycin/kg of body weight. At day 28, the overall clinical cure rate was 206 of 242 (85%). Clinical cure rates for patients infected with Streptococcus pneumoniae (67 of 76; 88%) and Haemophilus influenzae (28 of 44; 64%) were consistent with historical rates for the 5-day dosing regimen.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use*
  • Azithromycin / administration & dosage
  • Azithromycin / therapeutic use*
  • Child, Preschool
  • Combined Modality Therapy
  • Drainage
  • Female
  • Humans
  • Infant
  • Male
  • Otitis Media / drug therapy
  • Otitis Media / microbiology
  • Otitis Media / therapy*

Substances

  • Anti-Bacterial Agents
  • Azithromycin