Immunologic memory with no detectable bactericidal antibody response to a first dose of meningococcal serogroup C conjugate vaccine at four years

Jodie McVernon; Jenny MacLennan; Andrew J Pollard; Philipp Oster; Mark J Wakefield; Lisa Danzig; E Richard Moxon

Immunologic memory with no detectable bactericidal antibody response to a first dose of meningococcal serogroup C conjugate vaccine at four years

Pediatr Infect Dis J. 2003 Jul;22(7):659-61.

Authors

Jodie McVernon¹, Jenny MacLennan, Andrew J Pollard, Philipp Oster, Mark J Wakefield, Lisa Danzig, E Richard Moxon

Affiliation

¹ Oxford Vaccine Group, Department of Paediatrics, John Radcliffe Hospital, Headington, UK. [email protected]

PMID: 12886896

Abstract

Fourteen children with no detectable bactericidal antibody response to a first dose of meningococcal C conjugate vaccine at 4 years of age were given a booster dose of the same vaccine 2 years later. A rapid 1000-fold rise in postimmunization bactericidal antibody titers, a measured either 7 or 14 days later, suggested previous immunologic priming.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Bacterial / immunology*
Antibody Formation
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Humans
Immunization Schedule
Immunization, Secondary
Immunologic Memory / immunology*
Male
Meningococcal Infections / immunology*
Meningococcal Infections / prevention & control
Meningococcal Vaccines / administration & dosage*
Meningococcal Vaccines / immunology*
Neisseria meningitidis / immunology*
Probability
Prospective Studies
Sampling Studies
Sensitivity and Specificity
Time Factors

Substances

Antibodies, Bacterial
Meningococcal Vaccines
serogroup C meningococcal conjugate vaccine