Fatal lactic acidosis and mimicking Guillain-Barré syndrome in an adolescent with human immunodeficiency virus infection

Rafaella Rosso; Antonio Di Biagio; Antonio Ferrazin; Matteo Bassetti; Barbara Wenda Ciravegna; Dante Bassetti

Fatal lactic acidosis and mimicking Guillain-Barré syndrome in an adolescent with human immunodeficiency virus infection

Pediatr Infect Dis J. 2003 Jul;22(7):668-70.

Authors

Rafaella Rosso¹, Antonio Di Biagio, Antonio Ferrazin, Matteo Bassetti, Barbara Wenda Ciravegna, Dante Bassetti

Affiliation

¹ Department of Infectious Diseases, University of Genoa, School of Medicine, San Martino Hospital, Italy. [email protected]

PMID: 12886900

Abstract

We report a case of antiretroviral therapy-related fatal lactic acidosis occurring in a vertically infected HIV-positive 17-year-old patient. While receiving antiretroviral therapy with stavudine, didanosine, tenofovir and amprenavir, the patient developed severe acidosis and rapid neuromuscular and respiratory failure mimicking Guillain-Barré syndrome.

Publication types

Case Reports

MeSH terms

Acidosis, Lactic / chemically induced*
Acidosis, Lactic / physiopathology
Acidosis, Lactic / therapy
Adenine / adverse effects
Adenine / analogs & derivatives*
Adolescent
Antiretroviral Therapy, Highly Active / adverse effects*
Carbamates
Diagnosis, Differential
Didanosine / administration & dosage
Disease Progression
Drug Therapy, Combination
Fatal Outcome
Female
Furans
Guillain-Barre Syndrome / diagnosis*
HIV Infections / diagnosis
HIV Infections / drug therapy*
HIV Infections / transmission
Humans
Infectious Disease Transmission, Vertical
Organophosphonates*
Organophosphorus Compounds / adverse effects
Risk Assessment
Severity of Illness Index
Stavudine / adverse effects
Sulfonamides / adverse effects
Tenofovir

Substances

Carbamates
Furans
Organophosphonates
Organophosphorus Compounds
Sulfonamides
amprenavir
Tenofovir
Stavudine
Adenine
Didanosine