Abstract
Cyclin-dependent kinase 2 (CDK2) regulates diverse aspects of the mammalian cell cycle. Most cancer cells contain mutations in the pathways that control CDK2, and CDK2 activity has received much attention as a target for cancer therapy. However, a recent report demonstrating that some cancer cells can proliferate without CDK2 activity questions the essential role of CDK2 in cell-cycle control, as well as its suitability as a therapeutic target.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Comment
MeSH terms
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Animals
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CDC2-CDC28 Kinases / metabolism*
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Cell Cycle / physiology*
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Cell Cycle Proteins / metabolism
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Cell Line, Tumor / metabolism
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Cyclin-Dependent Kinase 2
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Cyclin-Dependent Kinase 4
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Cyclin-Dependent Kinase Inhibitor p27
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Cyclin-Dependent Kinases / metabolism
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Cyclins / metabolism
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DNA-Binding Proteins*
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E2F Transcription Factors
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G1 Phase / physiology
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Humans
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Models, Biological
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Nuclear Proteins / metabolism
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Nucleophosmin
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Phosphorylation
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Proto-Oncogene Proteins*
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Retinoblastoma Protein / metabolism
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Saccharomyces cerevisiae Proteins*
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Transcription Factor DP1
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Transcription Factors / metabolism
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Tumor Suppressor Proteins / metabolism
Substances
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CDC6 protein, S cerevisiae
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Cell Cycle Proteins
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Cyclins
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DNA-Binding Proteins
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E2F Transcription Factors
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NPAT protein, human
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Nuclear Proteins
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Proto-Oncogene Proteins
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Retinoblastoma Protein
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Saccharomyces cerevisiae Proteins
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Transcription Factor DP1
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Transcription Factors
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Tumor Suppressor Proteins
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Nucleophosmin
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Cyclin-Dependent Kinase Inhibitor p27
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CDC2-CDC28 Kinases
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CDK2 protein, human
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CDK4 protein, human
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Cyclin-Dependent Kinase 2
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Cyclin-Dependent Kinase 4
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Cyclin-Dependent Kinases