Facile and stereoselective synthesis of 2'-5'-oligothioadenylate by UO2(2+) ion catalyst

M Shimazu; K Shinozuka; H Sawai

Facile and stereoselective synthesis of 2'-5'-oligothioadenylate by UO2(2+) ion catalyst

Nucleic Acids Symp Ser. 1992:(27):105-6.

Authors

M Shimazu¹, K Shinozuka, H Sawai

Affiliation

¹ Department of Chemistry, Faculty of Engineering, Gunma University, Kiryu City, Japan.

PMID: 1289779

Abstract

The synthesis and characterization of 2'-5'-oligothioadenylate by UO2(2+) ion catalyst are described. The polymerization of imidazole-activated thioadenylate or thioinosylate yielded oligomers containing mainly 2'-5'-internucleotidyl blond and Rp configuration at phosphorous atom.

MeSH terms

Adenosine Monophosphate / analogs & derivatives*
Adenosine Monophosphate / chemical synthesis
Catalysis
Magnetic Resonance Spectroscopy
Molecular Conformation
Thionucleotides / chemical synthesis*
Uranium / chemistry*
Uranium Compounds*

Substances

Thionucleotides
Uranium Compounds
Adenosine Monophosphate
Uranium
uranium dioxide