Abstract
Iron overload increases oxidative stress and may lead to neurodegenerative disease like Parkinson's disease (PD). We studied the role of mutations in the hemochromatosis gene HFE in PD and other parkinsonism (non-PD PS) in two population-based series. The first series consisted of 137 patients with PD and 47 with non-PD PS, and the second of 60 patients with PD and 25 with non-PD PS. In the first series, PD patients were significantly more often homozygous for the C282Y mutation than controls (P=0.03). Patients with non-PD PS in both series were more often carriers for the C282Y mutation than controls (P=0.009, P=0.006, respectively). Our data are hampered by small numbers, yet suggest that the C282Y mutation increases the risk of PD and non-PD PS. The rarity of this genotype requires a large series of patients to prove our hypothesis.
MeSH terms
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Aged
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DNA Mutational Analysis
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Female
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Gene Frequency
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Genetic Predisposition to Disease / genetics*
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Genetic Testing
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Genotype
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Hemochromatosis / complications*
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Hemochromatosis / genetics*
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Hemochromatosis Protein
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Heterozygote
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Histocompatibility Antigens Class I / genetics*
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Homozygote
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Humans
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Iron / metabolism
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Male
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Membrane Proteins / genetics*
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Middle Aged
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Mutation / genetics*
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Neurons / metabolism
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Neurons / pathology
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Oxidative Stress / genetics
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Parkinson Disease / genetics*
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Parkinson Disease / metabolism
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Parkinson Disease / physiopathology
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Parkinsonian Disorders / genetics*
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Parkinsonian Disorders / metabolism
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Parkinsonian Disorders / physiopathology
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Substantia Nigra / metabolism
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Substantia Nigra / pathology
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Substantia Nigra / physiopathology
Substances
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HFE protein, human
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Hemochromatosis Protein
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Histocompatibility Antigens Class I
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Membrane Proteins
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Iron