Strains of Streptococcus pyogenes from severe invasive infections bind HEp2 and HaCaT cells more avidly than strains from uncomplicated infections

Mandy L Edwards; Peter K Fagan; Heidi Smith-Vaughan; Bart J Currie; Kadaba S Sriprakash

doi:10.1128/JCM.41.8.3936-3938.2003

Strains of Streptococcus pyogenes from severe invasive infections bind HEp2 and HaCaT cells more avidly than strains from uncomplicated infections

J Clin Microbiol. 2003 Aug;41(8):3936-8. doi: 10.1128/JCM.41.8.3936-3938.2003.

Authors

Mandy L Edwards¹, Peter K Fagan, Heidi Smith-Vaughan, Bart J Currie, Kadaba S Sriprakash

Affiliation

¹ Menzies School of Health Research. Cooperative Research Centre for Aboriginal and Tropical Health, Darwin, Australia.

Abstract

Epidemiologically unrelated Streptococcus pyogenes strains isolated from blood, throat, and skin were assayed for adherence to HEp2 and HaCaT cells. Invasive isolates showed significantly higher avidity for these cell lines than isolates from skin and throat. In general, S. pyogenes showed greater binding to HaCaT cells than to HEp2 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Adhesion / physiology*
Humans
Streptococcal Infections / diagnosis*
Streptococcus pyogenes / classification
Streptococcus pyogenes / isolation & purification*
Streptococcus pyogenes / physiology*
Tumor Cells, Cultured