Receptor-ligand binding: 'catch' bonds finally caught

Konstantinos Konstantopoulos; William D Hanley; Denis Wirtz

doi:10.1016/s0960-9822(03)00529-3

Receptor-ligand binding: 'catch' bonds finally caught

Curr Biol. 2003 Aug 5;13(15):R611-3. doi: 10.1016/s0960-9822(03)00529-3.

Authors

Konstantinos Konstantopoulos¹, William D Hanley, Denis Wirtz

Affiliation

¹ Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.

PMID: 12906816
DOI: 10.1016/s0960-9822(03)00529-3

Abstract

Leukocyte recruitment to sites of inflammation is initiated by the selectin family of adhesion receptors. Recent research reveals that P-selectin binding to its ligand exhibits 'catch' to 'slip' bond transition that may help explain the shear threshold phenomenon.

Publication types

Review

MeSH terms

Cell Adhesion
Ligands*
Membrane Glycoproteins / metabolism
Models, Molecular*
P-Selectin / metabolism*
Receptors, Leukocyte-Adhesion / metabolism*
Shear Strength

Substances

Ligands
Membrane Glycoproteins
P-Selectin
P-selectin ligand protein
Receptors, Leukocyte-Adhesion