Bone marrow necrosis and human parvovirus associated infection preceding an Ph1+ acute lymphoblastic leukemia

Leuk Lymphoma. 1992 Nov;8(4-5):415-9. doi: 10.3109/10428199209051023.

Abstract

A case of bone marrow necrosis associated with a serologically documented recent Parvovirus B 19 infection which preceded the development of PH1+ acute lymphoblastic leukemia is reported. No conclusions can be drawn on the basis of a single case but the question of the role of human Parvovirus B19 in the pathogenesis of bone marrow necrosis is discussed. It is suggested that the virus may act as a co-factor for the induction of bone marrow necrosis, in some cases.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Marrow / pathology*
  • Cyclophosphamide / administration & dosage
  • Daunorubicin / administration & dosage
  • Daunorubicin / analogs & derivatives
  • Erythema Infectiosum / complications*
  • Female
  • Humans
  • Karyotyping
  • Methotrexate / administration & dosage
  • Pancytopenia / etiology
  • Parvovirus B19, Human / pathogenicity*
  • Philadelphia Chromosome*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Prognosis
  • Remission Induction
  • Steroids / administration & dosage
  • Vincristine / administration & dosage

Substances

  • Steroids
  • Vincristine
  • Cyclophosphamide
  • Methotrexate
  • Daunorubicin

Supplementary concepts

  • LALA 87 protocol