Objective: To investigate the role of chloride channel ClC-2 and ClC-3 in human nasal polyps.
Method: Two chloride channels ClC-2 and ClC-3 were studied in 27 cases of nasal polyps with immunochemistric staining.
Result: Nasal polyps revealed strong positive staining of ClC-2 and ClC-3, the ClC-2 and ClC-3 proteins localized mainly in epithelial cells, sub-epithelial mucous glands without significant distinction. The number of positive cells of ClC-2 and ClC-3 are 17.6 +/- 6.33 and 23.49 +/- 6.14.
Conclusion: The chloride channels ClC-2 and ClC-3 may play a role in the formation of nasal polyps.