An improved procedure for the synthesis of benzimidazoles, using palladium-catalyzed aryl-amination chemistry

J Org Chem. 2003 Aug 22;68(17):6814-6. doi: 10.1021/jo034824l.

Abstract

New, improved conditions have been developed and optimized for the synthesis of benzimidazoles by intramolecular palladium-catalyzed aryl-amination chemistry. This methodology, combined with a "catch and release" purification strategy, has led to a range of these heterocycles being prepared rapidly and in excellent yield.

MeSH terms

  • Benzimidazoles / chemical synthesis*
  • Benzimidazoles / chemistry
  • Catalysis
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Palladium*

Substances

  • Benzimidazoles
  • Indicators and Reagents
  • Palladium