Pancreatic tumors are malignancies with poor prognosis. The total five-year survival is achieved only in 1-2% of patients of all stages. Only the surgical approach represent a curative treatment. Unfortunately, in the time of diagnosis, only 10-20% of tumours are in the resectable stages. The main reason is probably the low specificity of initial symptoms. Local control of this disease can be improved by adjuvant chemoradiotherapy, however, without effects on the overall survival. In potential resectable tumours the concomitant chemoradiotherapy can increase the probability of curative resection. Treatment of locally advanced inoperable tumours is considered as palliative treatment and therefore it is focused namely on the improvement of the quality of the patient's life. Supporting care must become an inseparable part of the concomitant chemoradiotherapy.