Reaction cascades initiated by nucleophilic attack of heteropentalene mesomeric betaine and nitrogen-rich mesoionic tetrazolium-5-amides on electron-deficient unsaturated compounds. Synthesis of novel heterocyclic systems

Org Biomol Chem. 2003 Mar 21;1(6):978-83. doi: 10.1039/b211000h.

Abstract

The reactions of heteropentalene mesomeric betaine 1 and nitrogen-rich mesoionic tetrazolium-5-amides 4, 11 and 16-18 with electron-deficient unsaturated compounds have been studied. Novel heterocyclic systems, tetrazolo[4,5-a][1,7]benzodiazonine inner salt 2 and 3-oxo-3,7-dihydro-2H-pyrazolo[3,4-b]pyridine 5, have been synthesized by the reactions of dimethyl acetylenedicarboxylate with 1 and tetrazolium-5-anilide 4, respectively, and fully characterized by X-ray crystallography. It has been found that the reactions of other tetrazolium-5-amides are also initiated by the nucleophilic addition of the electron-rich amide nitrogen to the electron-deficient unsaturated compounds.

MeSH terms

  • Amides / chemistry*
  • Azo Compounds / chemical synthesis
  • Betaine / analogs & derivatives*
  • Betaine / chemistry
  • Crystallography, X-Ray
  • Cyclization
  • Electrochemistry
  • Heterocyclic Compounds / chemical synthesis*
  • Models, Molecular
  • Molecular Structure
  • Nitrogen / chemistry
  • Pyridines / chemical synthesis
  • Stereoisomerism

Substances

  • Amides
  • Azo Compounds
  • Heterocyclic Compounds
  • Pyridines
  • Betaine
  • Nitrogen