Abstract
Berkeley Pit Lake in Butte, Montana, is an acid mine waste reservoir rich in toxic metals. A Pithomycessp. isolated from the Pit Lake yielded three tyrosine derivatives (1-3), one of which acts as a 5-HT((2a)) receptor ligand. This type of activity has been associated with migraine preventative and antihypertensive drugs. The isolation and characterization of compounds 1-3 and three sesquiterpenes (5-7) that have been isolated previously from higher plants are reported here.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Fungi / chemistry
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Ligands
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Montana
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NIH 3T3 Cells / drug effects
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Rats
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Receptor, Serotonin, 5-HT2A / drug effects*
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Sesquiterpenes* / chemistry
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Sesquiterpenes* / isolation & purification
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Sesquiterpenes* / pharmacology
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Tyrosine* / analogs & derivatives
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Tyrosine* / isolation & purification
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Tyrosine* / pharmacology
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Waste Products / analysis*
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Water / analysis*
Substances
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Ligands
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Receptor, Serotonin, 5-HT2A
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Sesquiterpenes
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Waste Products
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Water
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Tyrosine