Abstract
The synthesis of a new series of 1-methylcarbapenems having the substituted thiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. In particular, compounds 12b and 12k showed the most potent antibacterial activity.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology*
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Carbapenems / chemical synthesis*
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Carbapenems / pharmacology*
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Drug Stability
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Gram-Negative Bacteria / drug effects
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Gram-Negative Bacteria / growth & development
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Gram-Positive Bacteria / drug effects
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Gram-Positive Bacteria / growth & development
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Microbial Sensitivity Tests
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / growth & development
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Pyrrolidines / chemistry
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Structure-Activity Relationship
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Swine
Substances
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Anti-Bacterial Agents
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Carbapenems
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Pyrrolidines