Abstract
We tested the hypothesis that human immunodeficiency virus (HIV)-infected adults have a specific defect in anti-pneumococcal capsular polysaccharide (Pn-specific) immunoglobulin (Ig) in fluid obtained from the lower respiratory tract. Higher levels of total IgG and IgM were present in bronchoalveolar lavage samples from HIV-infected subjects than in those from HIV-uninfected subjects. Pn-specific IgG and IgM in bronchoalveolar lavage samples were not significantly different between HIV-infected and -uninfected subjects. After pneumococcal infection, HIV-infected patients had higher bronchoalveolar lavage levels of Pn-specific IgG than HIV-infected patients without recent infection (geometric means, 387 vs. 30 ng/mL, P=.001).
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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AIDS-Related Opportunistic Infections / immunology
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AIDS-Related Opportunistic Infections / microbiology
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Adult
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Antibodies, Bacterial / analysis*
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Antibodies, Bacterial / blood
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Antibody Specificity*
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Bacterial Capsules / immunology*
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Bronchoalveolar Lavage Fluid / immunology
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Female
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HIV Infections / immunology*
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Humans
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Immunoglobulin G / analysis
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Immunoglobulin G / blood
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Immunoglobulin M / analysis
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Immunoglobulin M / blood
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Lung / immunology*
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Malawi
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Male
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Pneumococcal Infections / immunology
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Respiratory Tract Infections / immunology
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Respiratory Tract Infections / microbiology
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Streptococcus pneumoniae / immunology*
Substances
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Antibodies, Bacterial
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Immunoglobulin G
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Immunoglobulin M