Effect of active synthetic 2-substituted quinazolinones on anti-platelet aggregation and the inhibition of superoxide anion generation by neutrophils

Fang-Rong Chang; Chin-Chung Wu; Tsong-Long Hwang; Ramesh Patnam; Reen-Yen Kuo; Wei-Ya Wang; Yu-Hsuan Lan; Yang-Chang Wu

doi:10.1007/BF02976872

Effect of active synthetic 2-substituted quinazolinones on anti-platelet aggregation and the inhibition of superoxide anion generation by neutrophils

Arch Pharm Res. 2003 Jul;26(7):511-5. doi: 10.1007/BF02976872.

Authors

Fang-Rong Chang¹, Chin-Chung Wu, Tsong-Long Hwang, Ramesh Patnam, Reen-Yen Kuo, Wei-Ya Wang, Yu-Hsuan Lan, Yang-Chang Wu

Affiliation

¹ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

PMID: 12934640
DOI: 10.1007/BF02976872

Abstract

Quinazolinones, 2-substituted and 3-substituted, mainly synthesized by microwave irradiation, were subjected to anti-platelet aggregation and inhibition of superoxide anion generation assays. Interestingly, 2-phenyl-4-quinazolinone (4) exhibited significant inhibitory activities toward platelet aggregation and neutrophil activation, and it might therefore serve as a prototype lead compound.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Animals
Humans
Neutrophils / drug effects*
Neutrophils / metabolism
Neutrophils / physiology*
Platelet Aggregation / drug effects*
Platelet Aggregation / physiology
Platelet Aggregation Inhibitors / chemistry
Platelet Aggregation Inhibitors / pharmacology*
Quinazolines / chemistry
Quinazolines / pharmacology*
Rabbits
Superoxides / antagonists & inhibitors*
Superoxides / metabolism
Technology, Pharmaceutical / methods

Substances

Platelet Aggregation Inhibitors
Quinazolines
Superoxides