Abstract
The antifungal and antibacterial agent cladobotryal (1) was synthesized by a convergent route from lactone 5 and aldehyde 12, a key step in the elaboration of the pyridinone ring being conversion of a t-BuOC(O) group on nitrogen into an i-Pr3SiOC(O) group.
MeSH terms
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / chemistry
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Furans / chemical synthesis*
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Furans / chemistry
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Pyridones / chemical synthesis*
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Pyridones / chemistry
Substances
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2-(2-buten-2-yl)-3,7-dihydro-3-formyl-3-methyl-5-phenylfuro(2,3-b)pyridin-4(2H)-one
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Anti-Infective Agents
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Antifungal Agents
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Furans
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Pyridones