Selective deficiency of naïve CD4+ T-lymphocytes in a child with congenital lymphoedema

Eur J Pediatr. 2003 Nov;162(11):752-4. doi: 10.1007/s00431-003-1295-7. Epub 2003 Aug 22.

Abstract

We describe the first known case of congenital lymphoedema associated with selective deficit of naïve CD4+ T-lymphocytes. A high proportion of naïve CD4+ T-lymphocytes was found in the ascitic fluid, supporting the hypothesis of extra-vascular sequestration of these cells into lymphoedematous tissue.

Publication types

  • Case Reports

MeSH terms

  • CD4-Positive T-Lymphocytes / physiology*
  • Congenital Abnormalities / diagnosis
  • Humans
  • Infant
  • Italy
  • L-Selectin / metabolism*
  • Lymphedema / congenital*
  • Lymphedema / diagnosis*
  • Male
  • Prognosis
  • Rare Diseases
  • Risk Assessment

Substances

  • L-Selectin