Abstract
The synthesis of a series of 1-aryl-1,6-dihydro-4H-thieno[3,4-c]pyrazol-4-ones by cyclization of 3-[(2-arylhydrazino)methylene]thiophene-2,4(3H,5H)-diones, prepared by reacting 3-dimethylaminomethylenethiophene-2,4(3H,5H)-dione with arylhydrazines, is described. The 4-fluorophenyl derivative showed remarkable analgesic, antiinflammatory and antipyretic activities in mice or rats, as well as a platelet antiaggregating activity in vitro comparable to that of acetylsalicylic acid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates
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Acetic Acid
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Carrageenan
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Edema / chemically induced
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Edema / prevention & control
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Fever / chemically induced
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Fever / prevention & control
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Humans
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Mice
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Pain / chemically induced
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Pain / prevention & control
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / chemical synthesis*
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Platelet Aggregation Inhibitors / pharmacology
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Pyrazoles / chemical synthesis*
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Pyrazoles / pharmacology
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Rats
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Yeast, Dried
Substances
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Acetates
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Anti-Inflammatory Agents, Non-Steroidal
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Platelet Aggregation Inhibitors
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Pyrazoles
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Carrageenan
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Acetic Acid